Publications

Lab Publications


 

Gaitán JM, Asthana S, Carlsson CM, Engelman CD, Johnson SC, Sager MA, Wang D, Dubal DB, Okonkwo OC. Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer’s Disease. J Alzheimers Dis. 2022 Oct 22. doi: 10.3233/JAD-220571.

Weiner MW, Veitch DP, Miller MJ, Aisen PS, Albala B, Beckett LA, Green RC, Harvey D, Jack CR Jr, Jagust W, Landau SM, Morris JC, Nosheny R, Okonkwo OC, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative. Increasing participant diversity in AD research: Plans for digital screening, blood testing, and a community-engaged approach in the Alzheimer’s Disease Neuroimaging Initiative 4. Alzheimers Dement. 2022 Oct 9. doi: 10.1002/alz.12797.

Peven JC, Handen BL, Laymon CM, Fleming V, Piro-Gambetti B, Christian BT, Klunk W, Cohen AD, Okonkwo O, Hartley SL. Physical activity, memory function, and hippocampal volume in adults with Down syndrome. Front Integr Neurosci. 2022 Sep 13;16:919711. doi: 10.3389/fnint.2022.919711.

Planalp EM, Okonkwo OC. Is 112 the New 10 000?-Step Count and Dementia Risk in the UK Biobank. JAMA Neurol. 2022 Oct 1;79(10):973-974. doi: 10.1001/jamaneurol.2022.2312.

Vesperman CJ, Wang R, Schultz SA, Law LL, Dougherty RJ, Ma Y, Oh JM, Edwards DF, Gallagher CL, Chin NA, Asthana S, Hermann BP, Sager MA, Johnson SC, Cook DB, Okonkwo OC. Cardiorespiratory fitness and cognition in persons at risk for Alzheimer’s disease. Alzheimers Dement (Amst). 2022 Jul 8;14(1):e12330. doi: 10.1002/dad2.12330.

Raman R, Aisen PS, Carillo MC, Detke M, Grill JD, Okonkwo OC, Rivera-Mindt M, Sabbagh M, Vellas B, Weiner M, Sperling R. Tackling a Major Deficiency of Diversity in Alzheimer’s Disease Therapeutic Trials: An CTAD Task Force Report. J Prev Alzheimers Dis. 2022;9(3):388-392. doi: 10.14283/jpad.2022.50

Mander BA, Dave A, Lui KK, Sprecher KE, Berisha D, Chappel-Farley MG, Chen IY, Riedner BA, Heston M, Suridjan I, Kollmorgen G, Zetterberg H, Blennow K, Carlsson CM, Okonkwo OC, Asthana S, Johnson SC, Bendlin BB, Benca RM. Inflammation, tau pathology, and synaptic integrity associated with sleep spindles and memory prior to β-amyloid positivity. Sleep. 2022 Sep 8;45(9):zsac135. doi: 10.1093/sleep/zsac135.

Bruno D, Jauregi Zinkunegi A, Pomara N, Zetterberg H, Blennow K, Koscik RL, Carlsson C, Bendlin B, Okonkwo O, Hermann BP, Johnson SC, Mueller KD. Cross-sectional associations of CSF tau levels with Rey’s AVLT: A recency ratio study. Neuropsychology. 2022 May 23. doi: 10.1037/neu0000821. Epub ahead of print.

Mill J, Patel V, Okonkwo O, Li L, Raife T. Erythrocyte sphingolipid species as biomarkers of Alzheimer’s disease. J Pharm Anal. 2022 Feb;12(1):178-185. doi: 10.1016/j.jpha.2021.07.005.

Ashford MT, Raman R, Miller G, Donohue MC, Okonkwo OC, Mindt MR, Nosheny RL, Coker GA, Petersen RC, Aisen PS, Weiner MW; Alzheimer’s Disease Neuroimaging Initiative. Screening and enrollment of underrepresented ethnocultural and educational populations in the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Alzheimers Dement. 2022 Feb 25:10.1002/alz.12640. doi: 10.1002/alz.12640.

Jonaitis EM, Zetterberg H, Koscik RL, Betthauser TJ, Van Hulle CA, Hogan K, Hegge L, Kollmorgen G, Suridjan I, Gleason CE, Engelman CD, Okonkwo OC, Asthana S, Bendlin BB, Carlsson CM, Johnson SC, Blennow K. Crosswalk study on blood collection-tube types for Alzheimer’s disease biomarkers. Alzheimers Dement (Amst). 2022 Feb 9;14(1):e12266. doi: 10.1002/dad2.12266.

Chen Z, Wang D, Yu Q, Johnson J, Shipman R, Zhong X, Huang J, Yu Q, Zetterberg H, Asthana S, Carlsson C, Okonkwo O, Li L. In-Depth Site-Specific O-Glycosylation Analysis of Glycoproteins and Endogenous Peptides in Cerebrospinal Fluid (CSF) from Healthy Individuals, Mild Cognitive Impairment (MCI), and Alzheimer’s Disease (AD) Patients. ACS Chem Biol. 2021 Dec 29:10.1021/acschembio.1c00932. doi: 10.1021/acschembio.1c00932.

Dougherty RJ, Lose SR, Gaitán JM, Mergen BM, Chin NA, Okonkwo OC, Cook DB. Five-year changes in objectively measured cardiorespiratory fitness, physical activity, and sedentary time in mid-to-late adulthood. Appl Physiol Nutr Metab. 2022 Feb;47(2):206-209. doi: 10.1139/apnm-2021-0500.

Levin F, Jelistratova I, Betthauser TJ, Okonkwo O, Johnson SC, Teipel SJ, Grothe MJ. In vivo staging of regional amyloid progression in healthy middle-aged to older people at risk of Alzheimer’s disease. Alzheimers Res Ther. 2021 Oct 21;13(1):178. doi: 10.1186/s13195-021-00918-0.

Edmunds KJ, Okonkwo OC, Sigurdsson S, Lose SR, Gudnason V, Carraro U, Gargiulo P. Soft tissue radiodensity parameters mediate the relationship between self-reported physical activity and lower extremity function in AGES-Reykjavík participants. Sci Rep. 2021 Oct 11;11(1):20173. doi: 10.1038/s41598-021-99699-7.

Veitch DP, Weiner MW, Aisen PS, Beckett LA, DeCarli C, Green RC, Harvey D, Jack CR Jr, Jagust W, Landau SM, Morris JC, Okonkwo O, Perrin RJ, Petersen RC, Rivera-Mindt M, Saykin AJ, Shaw LM, Toga AW, Tosun D, Trojanowski JQ; Alzheimer’s Disease Neuroimaging Initiative. Using the Alzheimer’s Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer’s disease. Alzheimers Dement. 2022 Apr;18(4):824-857. doi: 10.1002/alz.12422.

Smith GE, Okonkwo OC. Truly Cross-fit: The Association of Exercise and Clinical Outcomes: Introduction to a JINS Special Section. J Int Neuropsychol Soc. 2021 Sep;27(8):757-760. doi: 10.1017/S1355617721001119.

Fleming V, Piro-Gambetti B, Patrick A, Zammit M, Alexander A, Christian BT, Handen B, Cohen A, Klunk W, Laymon C, Ances BM, Plante DT, Okonkwo O, Hartley SL. Physical activity and cognitive and imaging biomarkers of Alzheimer’s disease in down syndrome. Neurobiol Aging. 2021 Nov;107:118-127. doi: 10.1016/j.neurobiolaging.2021.07.016..

Langhough Koscik R, Hermann BP, Allison S, Clark LR, Jonaitis EM, Mueller KD, Betthauser TJ, Christian BT, Du L, Okonkwo O, Birdsill A, Chin N, Gleason C, Johnson SC. Validity Evidence for the Research Category, “Cognitively Unimpaired – Declining,” as a Risk Marker for Mild Cognitive Impairment and Alzheimer’s Disease. Front Aging Neurosci. 2021 Jul 26;13:688478. doi: 10.3389/fnagi.2021.688478.

Shadyab AH, LaCroix AZ, Feldman HH, van Dyck CH, Okonkwo OC, Tam SP, Fairchild JK, Welsh-Bohmer KA, Matthews G, Bennett D, Shadyab AA, Schafer KA, Morrison RH, Kipperman SA, Mason J, Tan D, Thomas RG, Cotman CW, Baker LD; ADCS EXERT Study Group. Recruitment of a multi-site randomized controlled trial of aerobic exercise for older adults with amnestic mild cognitive impairment: The EXERT trial. Alzheimers Dement. 2021 Nov;17(11):1808-1817. doi: 10.1002/alz.12401.

Dougherty RJ, Jonaitis EM, Gaitán JM, Lose SR, Mergen BM, Johnson SC, Okonkwo OC, Cook DB. Cardiorespiratory fitness mitigates brain atrophy and cognitive decline in adults at risk for Alzheimer’s disease. Alzheimers Dement (Amst). 2021 Jul 12;13(1):e12212. doi: 10.1002/dad2.12212.

Driscoll I, Ma Y, Gallagher CL, Johnson SC, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Carlsson CM, Engelman CD, Dubal DB, Okonkwo OC. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes. J Alzheimers Dis. 2021;82(3):1369-1370. doi: 10.3233/JAD-219006. Erratum for: J Alzheimers Dis. 2021;79(3):1297-1305.

Wang R, Oh JM, Motovylyak A, Ma Y, Sager MA, Rowley HA, Johnson KM, Gallagher CL, Carlsson CM, Bendlin BB, Johnson SC, Asthana S, Eisenmenger L, Okonkwo OC. Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study. J Cereb Blood Flow Metab. 2021 Nov;41(11):3016-3027. doi: 10.1177/0271678X211021313.

Gaitán JM, Moon HY, Stremlau M, Dubal DB, Cook DB, Okonkwo OC, van Praag H. Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease. Front Endocrinol (Lausanne). 2021 May 20;12:660181. doi: 10.3389/fendo.2021.660181.

Ma Y, Norton DL, Van Hulle CA, Chappell RJ, Lazar KK, Jonaitis EM, Koscik RL, Clark LR, Krause R, Andreasson U, Chin NA, Bendlin BB, Asthana S, Okonkwo OC, Gleason CE, Johnson SC, Zetterberg H, Blennow K, Carlsson CM. Measurement batch differences and between-batch conversion of Alzheimer’s disease cerebrospinal fluid biomarker values. Alzheimers Dement (Amst). 2021 May 25;13(1):e12194. doi: 10.1002/dad2.12194.

Chen Z, Yu Q, Yu Q, Johnson J, Shipman R, Zhong X, Huang J, Asthana S, Carlsson C, Okonkwo O, Li L. In-depth Site-specific Analysis of N-glycoproteome in Human Cerebrospinal Fluid and Glycosylation Landscape Changes in Alzheimer’s Disease. Mol Cell Proteomics. 2021;20:100081. doi: 10.1016/j.mcpro.2021.100081.

Hunt JFV, Vogt NM, Jonaitis EM, Buckingham WR, Koscik RL, Zuelsdorff M, Clark LR, Gleason CE, Yu M, Okonkwo O, Johnson SC, Asthana S, Bendlin BB, Kind AJH. Association of Neighborhood Context, Cognitive Decline, and Cortical Change in an Unimpaired Cohort. Neurology. 2021 May 18;96(20):e2500-e2512. doi: 10.1212/WNL.0000000000011918. Epub 2021 Apr 14.

Driscoll I, Ma Y, Gallagher CL, Johnson SC, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Carlsson CM, Engelman CD, Dubal DB, Okonkwo OC. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes. J Alzheimers Dis. 2021;79(3):1297-1305. doi: 10.3233/JAD-200944. Erratum in: J Alzheimers Dis. 2021;82(3):1369-1370.

Van Hulle C, Jonaitis EM, Betthauser TJ, Batrla R, Wild N, Kollmorgen G, Andreasson U, Okonkwo O, Bendlin BB, Asthana S, Carlsson CM, Johnson SC, Zetterberg H, Blennow K. An examination of a novel multipanel of CSF biomarkers in the Alzheimer’s disease clinical and pathological continuum. Alzheimers Dement. 2021 Mar;17(3):431-445. doi: 10.1002/alz.12204.

Maxa KM, Hoffman C, Rivera-Rivera LA, Motovylyak A, Turski PA, Mitchell CKC, Ma Y, Berman SE, Gallagher CL, Bendlin BB, Asthana S, Sager MA, Hermann BP, Johnson SC, Cook DB, Wieben O, Okonkwo OC. Cardiorespiratory Fitness Associates with Cerebral Vessel Pulsatility in a Cohort Enriched with Risk for Alzheimer’s Disease. Brain Plast. 2020 Oct 1;5(2):175-184. doi: 10.3233/BPL-190096.

Bartrés-Faz D, Arenaza-Urquijo E, Ewers M, Belleville S, Chételat G, Franzmeier N, Gonneaud J, de Echevarri JMG, Okonkwo O, Schultz S, Valenzuela M, Stern Y, Vemuri P. Theoretical frameworks and approaches used within the Reserve, Resilience and Protective Factors professional interest area of the Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment. Alzheimers Dement (Amst). 2020 Nov 11;12(1):e12115. doi: 10.1002/dad2.12115.

Fields TN, Mueller KD, Koscik RL, Johnson SC, Okonkwo OC, Litovsky RY. Self-Reported Hearing Loss and Longitudinal Cognitive Function in a Cohort Enriched with Risk for Alzheimer’s Disease. J Alzheimers Dis. 2020;78(3):1109-1117. doi: 10.3233/JAD-200701.

Morris JK, Zhang G, Dougherty RJ, Mahnken JD, John CS, Lose SR, Cook DB, Burns JM, Vidoni ED, Okonkwo O. Collective effects of age, sex, genotype, and cognitive status on fitness outcomes. Alzheimers Dement (Amst). 2020 Jul 13;12(1):e12058. doi: 10.1002/dad2.12058.

Gaitán JM, Boots EA, Dougherty RJ, Ma Y, Edwards DF, Mitchell CC, Christian BT, Cook DB, Okonkwo OC. Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study. J Alzheimers Dis Rep. 2020 May 2;4(1):107-121. doi: 10.3233/ADR-200180.

Mueller KD, Norton D, Koscik RL, Morris MC, Jonaitis EM, Clark LR, Fields T, Allison S, Berman S, Kraning S, Zuelsdorff M, Okonkwo O, Chin N, Carlsson CM, Bendlin BB, Hermann BP, Johnson SC. Self-reported health behaviors and longitudinal cognitive performance in late middle age: Results from the Wisconsin Registry for Alzheimer’s Prevention. PLoS One. 2020 Apr 23;15(4):e0221985. doi: 10.1371/journal.pone.0221985.

Gaitán JM, Boots EA, Dougherty RJ, Oh JM, Ma Y, Edwards DF, Christian BT, Cook DB, Okonkwo OC. Brain Glucose Metabolism, Cognition, and Cardiorespiratory Fitness Following Exercise Training in Adults at Risk for Alzheimer’s Disease. Brain Plast. 2019 Dec 26;5(1):83-95. doi: 10.3233/BPL-190093.

Okonkwo O, van Praag H. Exercise Effects on Cognitive Function in Humans. Brain Plast. 2019 Dec 26;5(1):1-2. doi: 10.3233/BPL-199001.

Hunt JFV, Buckingham W, Kim AJ, Oh J, Vogt NM, Jonaitis EM, Hunt TK, Zuelsdorff M, Powell R, Norton D, Rissman RA, Asthana S, Okonkwo OC, Johnson SC, Kind AJH, Bendlin BB. Association of Neighborhood-Level Disadvantage With Cerebral and Hippocampal Volume. JAMA Neurol. 2020 Apr 1;77(4):451-460. doi: 10.1001/jamaneurol.2019.4501. Erratum in: JAMA Neurol. 2020 Feb 17;:

Zuelsdorff M, Okonkwo OC, Norton D, Barnes LL, Graham KL, Clark LR, Wyman MF, Benton SF, Gee A, Lambrou N, Johnson SC, Gleason CE. Stressful Life Events and Racial Disparities in Cognition Among Middle-Aged and Older Adults. J Alzheimers Dis. 2020;73(2):671-682. doi: 10.3233/JAD-190439.

Gallagher M, Okonkwo OC, Resnick SM, Jagust WJ, Benzinger TLS, Rapp PR. What are the threats to successful brain and cognitive aging? Neurobiol Aging. 2019 Nov;83:130-134. doi: 10.1016/j.neurobiolaging.2019.04.016.

O’Grady JP, Dean DC 3rd, Yang KL, Canda CM, Hoscheidt SM, Starks EJ, Merluzzi A, Hurley S, Davenport NJ, Okonkwo OC, Anderson RM, Asthana S, Johnson SC, Alexander AL, Bendlin BB. Elevated Insulin and Insulin Resistance are Associated with Altered Myelin in Cognitively Unimpaired Middle-Aged Adults. Obesity (Silver Spring). 2019 Sep;27(9):1464-1471. doi: 10.1002/oby.22558.

Okonkwo O. Program Guide for Division 40 (Society forClinical Neuropsychology) at the annual Convention of the American Psychological Association, August 8-11, 2019; Chicago, IL. Clin Neuropsychol. 2019 Oct;33(7):1216-1348. doi: 10.1080/13854046.2019.1628306.

Pozorski V, Oh JM, Okonkwo O, Krislov S, Barzgari A, Theisen F, Sojkova J, Bendlin BB, Johnson SC, Gallagher CL. Cross-sectional and longitudinal associations between total and regional white matter hyperintensity volume and cognitive and motor function in Parkinson’s disease. Neuroimage Clin. 2019;23:101870. doi: 10.1016/j.nicl.2019.101870.

Law LL, Sprecher KE, Dougherty RJ, Edwards DF, Koscik RL, Gallagher CL, Carlsson CM, Zetterberg H, Blennow K, Asthana S, Sager MA, Hermann BP, Johnson SC, Cook DB, Bendlin BB, Okonkwo OC. Cardiorespiratory Fitness Modifies Influence of Sleep Problems on Cerebrospinal Fluid Biomarkers in an At-Risk Cohort. J Alzheimers Dis. 2019;69(1):111-121. doi: 10.3233/JAD-180291.

Mihaila I, Handen BL, Christian BT, Lao PJ, Cody KA, Klunk WE, Tudorascu DL, Cohen AD, Okonkwo OC, Hartley SL. Leisure Activity, Brain β-amyloid, and Episodic Memory in Adults with Down Syndrome. Dev Neurobiol. 2019 Jul;79(7):738-749. doi: 10.1002/dneu.22677.

Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC. KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD. Neurology. 2019 Apr 16;92(16):e1878-e1889. doi: 10.1212/WNL.0000000000007323.

Dougherty RJ, Boots EA, Lindheimer JB, Stegner AJ, Van Riper S, Edwards DF, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Sager MA, Johnson SC, Okonkwo OC, Cook DB. Fitness, independent of physical activity is associated with cerebral blood flow in adults at risk for Alzheimer’s disease. Brain Imaging Behav. 2020 Aug;14(4):1154-1163. doi: 10.1007/s11682-019-00068-w.

Stern Y, Chételat G, Habeck C, Arenaza-Urquijo EM, Vemuri P, Estanga A, Bartrés-Faz D, Cantillon M, Clouston SAP, Elman JA, Gold BT, Jones R, Kempermann G, Lim YY, van Loenhoud A, Martínez-Lage P, Morbelli S, Okonkwo O, Ossenkoppele R, Pettigrew C, Rosen AC, Scarmeas N, Soldan A, Udeh-Momoh C, Valenzuela M, Vuoksimaa E. Mechanisms underlying resilience in ageing. Nat Rev Neurosci. 2019 Apr;20(4):246. doi: 10.1038/s41583-019-0138-0.

Zhong X, Wang J, Carlsson C, Okonkwo O, Zetterberg H, Li L. A Strategy for Discovery and Verification of Candidate Biomarkers in Cerebrospinal Fluid of Preclinical Alzheimer’s Disease. Front Mol Neurosci. 2019 Jan 7;11:483. doi: 10.3389/fnmol.2018.00483.

Zhong X, Yu Q, Ma F, Frost DC, Lu L, Chen Z, Zetterberg H, Carlsson C, Okonkwo O, Li L. HOTMAQ: A Multiplexed Absolute Quantification Method for Targeted Proteomics. Anal Chem. 2019 Feb 5;91(3):2112-2119. doi: 10.1021/acs.analchem.8b04580.

Vesperman CJ, Pozorski V, Dougherty RJ, Law LL, Boots E, Oh JM, Gallagher CL, Carlsson CM, Rowley HA, Ma Y, Bendlin BB, Asthana S, Sager MA, Hermann BP, Johnson SC, Cook DB, Okonkwo OC. Cardiorespiratory fitness attenuates age-associated aggregation of white matter hyperintensities in an at-risk cohort. Alzheimers Res Ther. 2018 Sep 24;10(1):97. doi: 10.1186/s13195-018-0429-0.

Stern Y, Arenaza-Urquijo EM, Bartrés-Faz D, Belleville S, Cantilon M, Chetelat G, Ewers M, Franzmeier N, Kempermann G, Kremen WS, Okonkwo O, Scarmeas N, Soldan A, Udeh-Momoh C, Valenzuela M, Vemuri P, Vuoksimaa E; the Reserve, Resilience and Protective Factors PIA Empirical Definitions and Conceptual Frameworks Workgroup. Whitepaper: Defining and investigating cognitive reserve, brain reserve, and brain maintenance. Alzheimers Dement. 2020 Sep;16(9):1305-1311. doi: 10.1016/j.jalz.2018.07.219.

Pozorski V, Oh JM, Adluru N, Merluzzi AP, Theisen F, Okonkwo O, Barzgari A, Krislov S, Sojkova J, Bendlin BB, Johnson SC, Alexander AL, Gallagher CL. Longitudinal white matter microstructural change in Parkinson’s disease. Hum Brain Mapp. 2018 Oct;39(10):4150-4161. doi: 10.1002/hbm.24239.

Hao L, Wang J, Page D, Asthana S, Zetterberg H, Carlsson C, Okonkwo OC, Li L. Comparative Evaluation of MS-based Metabolomics Software and Its Application to Preclinical Alzheimer’s Disease. Sci Rep. 2018 Jun 18;8(1):9291. doi: 10.1038/s41598-018-27031-x.

Barzgari A, Sojkova J, Maritza Dowling N, Pozorski V, Okonkwo OC, Starks EJ, Oh J, Thiesen F, Wey A, Nicholas CR, Johnson S, Gallagher CL. Arterial spin labeling reveals relationships between resting cerebral perfusion and motor learning in Parkinson’s disease. Brain Imaging Behav. 2019 Jun;13(3):577-587. doi: 10.1007/s11682-018-9877-1.

Law LL, Rol RN, Schultz SA, Dougherty RJ, Edwards DF, Koscik RL, Gallagher CL, Carlsson CM, Bendlin BB, Zetterberg H, Blennow K, Asthana S, Sager MA, Hermann BP, Johnson SC, Cook DB, Okonkwo OC. Moderate intensity physical activity associates with CSF biomarkers in a cohort at risk for Alzheimer’s disease. Alzheimers Dement (Amst). 2018 Feb 6;10:188-195. doi: 10.1016/j.dadm.2018.01.001.

Johnson SC, Koscik RL, Jonaitis EM, Clark LR, Mueller KD, Berman SE, Bendlin BB, Engelman CD, Okonkwo OC, Hogan KJ, Asthana S, Carlsson CM, Hermann BP, Sager MA. The Wisconsin Registry for Alzheimer’s Prevention: A review of findings and current directions. Alzheimers Dement (Amst). 2017 Dec 8;10:130-142. doi: 10.1016/j.dadm.2017.11.007.

Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD. Social support and verbal interaction are differentially associated with cognitive function in midlife and older age. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2019 Mar;26(2):144-160. doi: 10.1080/13825585.2017.1414769.

Dougherty RJ, Lindheimer JB, Stegner AJ, Van Riper S, Okonkwo OC, Cook DB. An Objective Method to Accurately Measure Cardiorespiratory Fitness in Older Adults Who Cannot Satisfy Widely Used Oxygen Consumption Criteria. J Alzheimers Dis. 2018;61(2):601-611. doi: 10.3233/JAD-170576.

Theisen F, Leda R, Pozorski V, Oh JM, Adluru N, Wong R, Okonkwo O, Dean DC 3rd, Bendlin BB, Johnson SC, Alexander AL, Gallagher CL. Evaluation of striatonigral connectivity using probabilistic tractography in Parkinson’s disease. Neuroimage Clin. 2017 Sep 9;16:557-563. doi: 10.1016/j.nicl.2017.09.009.

Curtin KB, Watson AE, Wang J, Okonkwo OC, Lyon ME. Pediatric advance care planning (pACP) for teens with cancer and their families: Design of a dyadic, longitudinal RCCT. Contemp Clin Trials. 2017 Nov;62:121-129. doi: 10.1016/j.cct.2017.08.016.

Sprecher KE, Koscik RL, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Sager MA, Asthana S, Johnson SC, Benca RM, Bendlin BB. Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults. Neurology. 2017 Aug 1;89(5):445-453. doi: 10.1212/WNL.0000000000004171.

Lassen-Greene CL, Steward K, Okonkwo O, Porter E, Crowe M, Vance DE, Griffith HR, Ball K, Marson DC, Wadley VG. Mild Cognitive Impairment and Changes in Everyday Function Over Time: The Importance of Evaluating Both Speed and Accuracy. J Geriatr Psychiatry Neurol. 2017 Jul;30(4):220-227. doi: 10.1177/0891988717711807.

Zuelsdorff ML, Koscik RL, Okonkwo OC, Peppard PE, Hermann BP, Sager MA, Johnson SC, Engelman CD. Reliability of a Novel Social Activity Questionnaire: Perceived Social Support and Verbal Interaction in the Wisconsin Registry for Alzheimer’s Prevention. J Aging Health. 2018 Feb;30(2):305-320. doi: 10.1177/0898264316674812.

Dougherty RJ, Schultz SA, Kirby TK, Boots EA, Oh JM, Edwards D, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Johnson SC, Cook DB, Okonkwo OC. Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer’s Disease. J Alzheimers Dis. 2017;58(4):1089-1097. doi: 10.3233/JAD-161067.

Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, Engelman CD, Johnson SC, Okonkwo OC. BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer’s Prevention. Neurology. 2017 May 30;88(22):2098-2106. doi: 10.1212/WNL.0000000000003980.

Schultz SA, Boots EA, Darst BF, Zetterberg H, Blennow K, Edwards DF, Koscik RL, Carlsson CM, Gallagher CL, Bendlin BB, Asthana S, Sager MA, Hogan KJ, Hermann BP, Cook DB, Johnson SC, Engelman CD, Okonkwo OC. Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD. Neurology. 2017 Apr 25;88(17):1650-1658. doi: 10.1212/WNL.0000000000003862.

Dougherty RJ, Schultz SA, Boots EA, Ellingson LD, Meyer JD, Van Riper S, Stegner AJ, Edwards DF, Oh JM, Einerson J, Korcarz CE, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Sager MA, Stein JH, Johnson SC, Okonkwo OC, Cook DB. Relationships between cardiorespiratory fitness, hippocampal volume, and episodic memory in a population at risk for Alzheimer’s disease. Brain Behav. 2017 Feb 17;7(3):e00625. doi: 10.1002/brb3.625.

Hoy AR, Ly M, Carlsson CM, Okonkwo OC, Zetterberg H, Blennow K, Sager MA, Asthana S, Johnson SC, Alexander AL, Bendlin BB. Microstructural white matter alterations in preclinical Alzheimer’s disease detected using free water elimination diffusion tensor imaging. PLoS One. 2017 Mar 14;12(3):e0173982. doi: 10.1371/journal.pone.0173982.

Okonkwo OC, Vemuri P. Stemming the Alzheimer tsunami: introduction to the special issue on reserve and resilience in Alzheimer’s disease. Brain Imaging Behav. 2017 Apr;11(2):301-303. doi: 10.1007/s11682-017-9677-z.

Law LL, Schultz SA, Boots EA, Einerson JA, Dougherty RJ, Oh JM, Korcarz CE, Edwards DF, Koscik RL, Dowling NM, Gallagher CL, Bendlin BB, Carlsson CM, Asthana S, Hermann BP, Sager MA, Johnson SC, Cook DB, Stein JH, Okonkwo OC. Chronotropic Response and Cognitive Function in a Cohort at Risk for Alzheimer’s Disease. J Alzheimers Dis. 2017;56(1):351-359. doi: 10.3233/JAD-160642.

Koscik RL, Berman SE, Clark LR, Mueller KD, Okonkwo OC, Gleason CE, Hermann BP, Sager MA, Johnson SC. Intraindividual Cognitive Variability in Middle Age Predicts Cognitive Impairment 8-10 Years Later: Results from the Wisconsin Registry for Alzheimer’s Prevention. J Int Neuropsychol Soc. 2016 Nov;22(10):1016-1025. doi: 10.1017/S135561771600093X.

Okonkwo OC, Asthana S. Dementia Trends in the United States: Read Up and Weigh In. JAMA Intern Med. 2017 Jan 1;177(1):58-60. doi: 10.1001/jamainternmed.2016.7073.

Okonkwo OC, Simons A, Nichani J; North West ENT Research Collaborative. Paediatric airway foreign body – The human factors influencing patient safety in our hospitals. Int J Pediatr Otorhinolaryngol. 2016 Dec;91:100-104. doi: 10.1016/j.ijporl.2016.10.016.

Wang J, Cunningham R, Zetterberg H, Asthana S, Carlsson C, Okonkwo O, Li L. Label-free quantitative comparison of cerebrospinal fluid glycoproteins and endogenous peptides in subjects with Alzheimer’s disease, mild cognitive impairment, and healthy individuals. Proteomics Clin Appl. 2016 Dec;10(12):1225-1241. doi: 10.1002/prca.201600009.

Dean DC 3rd, Sojkova J, Hurley S, Kecskemeti S, Okonkwo O, Bendlin BB, Theisen F, Johnson SC, Alexander AL, Gallagher CL. Alterations of Myelin Content in Parkinson’s Disease: A Cross-Sectional Neuroimaging Study. PLoS One. 2016 Oct 5;11(10):e0163774. doi: 10.1371/journal.pone.0163774.

Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD. Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer’s Disease. J Alzheimers Dis. 2017;55(2):473-484. doi: 10.3233/JAD-160195.

Dougherty RJ, Ellingson LD, Schultz SA, Boots EA, Meyer JD, Lindheimer JB, Van Riper S, Stegner AJ, Edwards DF, Oh JM, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Sager MA, Johnson SC, Okonkwo OC, Cook DB. Meeting physical activity recommendations may be protective against temporal lobe atrophy in older adults at risk for Alzheimer’s disease. Alzheimers Dement (Amst). 2016 Apr 9;4:14-7. doi: 10.1016/j.dadm.2016.03.005.

Racine AM, Koscik RL, Berman SE, Nicholas CR, Clark LR, Okonkwo OC, Rowley HA, Asthana S, Bendlin BB, Blennow K, Zetterberg H, Gleason CE, Carlsson CM, Johnson SC. Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife. Brain. 2016 Aug;139(Pt 8):2261-74. doi: 10.1093/brain/aww142.

Merluzzi AP, Dean DC 3rd, Adluru N, Suryawanshi GS, Okonkwo OC, Oh JM, Hermann BP, Sager MA, Asthana S, Zhang H, Johnson SC, Alexander AL, Bendlin BB. Age-dependent differences in brain tissue microstructure assessed with neurite orientation dispersion and density imaging. Neurobiol Aging. 2016 Jul;43:79-88. doi: 10.1016/j.neurobiolaging.2016.03.026.

Clark LR, Koscik RL, Nicholas CR, Okonkwo OC, Engelman CD, Bratzke LC, Hogan KJ, Mueller KD, Bendlin BB, Carlsson CM, Asthana S, Sager MA, Hermann BP, Johnson SC. Mild Cognitive Impairment in Late Middle Age in the Wisconsin Registry for Alzheimer’s Prevention Study: Prevalence and Characteristics Using Robust and Standard Neuropsychological Normative Data. Arch Clin Neuropsychol. 2016 Nov 22;31(7):675-688. doi: 10.1093/arclin/acw024.

Kim WH, Ravi SN, Johnson SC, Okonkwo OC, Singh V. On Statistical Analysis of Neuroimages with Imperfect Registration. Proc IEEE Int Conf Comput Vis. 2015 Dec;2015:666-674. doi: 10.1109/ICCV.2015.83.

Racine AM, Koscik RL, Nicholas CR, Clark LR, Okonkwo OC, Oh JM, Hillmer AT, Murali D, Barnhart TE, Betthauser TJ, Gallagher CL, Rowley HA, Dowling NM, Asthana S, Bendlin BB, Blennow K, Zetterberg H, Carlsson CM, Christian BT, Johnson SC. Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation. Alzheimers Dement (Amst). 2016;2:27-38. doi: 10.1016/j.dadm.2015.11.006.

Ly M, Adluru N, Destiche DJ, Lu SY, Oh JM, Hoscheidt SM, Alexander AL, Okonkwo OC, Rowley HA, Sager MA, Johnson SC, Bendlin BB. Fornix Microstructure and Memory Performance Is Associated with Altered Neural Connectivity during Episodic Recognition. J Int Neuropsychol Soc. 2016 Feb;22(2):191-204. doi: 10.1017/S1355617715001216.

Melah KE, Lu SY, Hoscheidt SM, Alexander AL, Adluru N, Destiche DJ, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Gleason CE, Dowling NM, Bratzke LC, Rowley HA, Sager MA, Asthana S, Johnson SC, Bendlin BB. Cerebrospinal Fluid Markers of Alzheimer’s Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer’s Disease. J Alzheimers Dis. 2016;50(3):873-86. doi: 10.3233/JAD-150897.

Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC. Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer’s Prevention study. Alzheimers Dement. 2016 Jul;12(7):805-14. doi: 10.1016/j.jalz.2015.12.009.

Schultz SA, Boots EA, Almeida RP, Oh JM, Einerson J, Korcarz CE, Edwards DF, Koscik RL, Dowling MN, Gallagher CL, Bendlin BB, Christian BT, Zetterberg H, Blennow K, Carlsson CM, Asthana S, Hermann BP, Sager MA, Johnson SC, Stein JH, Okonkwo OC. Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition. J Int Neuropsychol Soc. 2015 Nov;21(10):841-50. doi: 10.1017/S1355617715000843.

Willette AA, Bendlin BB, Starks EJ, Birdsill AC, Johnson SC, Christian BT, Okonkwo OC, La Rue A, Hermann BP, Koscik RL, Jonaitis EM, Sager MA, Asthana S. Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease. JAMA Neurol. 2015 Sep;72(9):1013-20. doi: 10.1001/jamaneurol.2015.0613. Erratum in: JAMA Neurol. 2015 Dec;72(12):1537. Erratum in: JAMA Neurol. 2017 Jul 1;74(7):873.

Doherty BM, Schultz SA, Oh JM, Koscik RL, Dowling NM, Barnhart TE, Murali D, Gallagher CL, Carlsson CM, Bendlin BB, LaRue A, Hermann BP, Rowley HA, Asthana S, Sager MA, Christian BT, Johnson SC, Okonkwo OC. Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer’s Prevention. Alzheimers Dement (Amst). 2015 Jun 1;1(2):160-169. doi: 10.1016/j.dadm.2015.01.003.

Boots EA, Schultz SA, Almeida RP, Oh JM, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Sager MA, Hermann BP, Johnson SC, Okonkwo OC. Occupational Complexity and Cognitive Reserve in a Middle-Aged Cohort at Risk for Alzheimer’s Disease. Arch Clin Neuropsychol. 2015 Nov;30(7):634-42. doi: 10.1093/arclin/acv041.

Ithapu VK, Singh V, Okonkwo OC, Chappell RJ, Dowling NM, Johnson SC; Alzheimer’s Disease Neuroimaging Initiative. Imaging-based enrichment criteria using deep learning algorithms for efficient clinical trials in mild cognitive impairment. Alzheimers Dement. 2015 Dec;11(12):1489-1499. doi: 10.1016/j.jalz.2015.01.010.

Sprecher KE, Bendlin BB, Racine AM, Okonkwo OC, Christian BT, Koscik RL, Sager MA, Asthana S, Johnson SC, Benca RM. Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults. Neurobiol Aging. 2015 Sep;36(9):2568-76. doi: 10.1016/j.neurobiolaging.2015.05.004.

Kim WH, Adluru N, Chung MK, Okonkwo OC, Johnson SC, B Bendlin B, Singh V. Multi-resolution statistical analysis of brain connectivity graphs in preclinical Alzheimer’s disease. Neuroimage. 2015 Sep;118:103-17. doi: 10.1016/j.neuroimage.2015.05.050..

Schultz SA, Oh JM, Koscik RL, Dowling NM, Gallagher CL, Carlsson CM, Bendlin BB, LaRue A, Hermann BP, Rowley HA, Asthana S, Sager MA, Johnson SC, Okonkwo OC. Subjective memory complaints, cortical thinning, and cognitive dysfunction in middle-aged adults at risk for AD. Alzheimers Dement (Amst). 2015 Mar 1;1(1):33-40. doi: 10.1016/j.dadm.2014.11.010.

Almeida RP, Schultz SA, Austin BP, Boots EA, Dowling NM, Gleason CE, Bendlin BB, Sager MA, Hermann BP, Zetterberg H, Carlsson CM, Johnson SC, Asthana S, Okonkwo OC. Effect of Cognitive Reserve on Age-Related Changes in Cerebrospinal Fluid Biomarkers of Alzheimer Disease. JAMA Neurol. 2015 Jun;72(6):699-706. doi: 10.1001/jamaneurol.2015.0098.

Starks EJ, Patrick O’Grady J, Hoscheidt SM, Racine AM, Carlsson CM, Zetterberg H, Blennow K, Okonkwo OC, Puglielli L, Asthana S, Dowling NM, Gleason CE, Anderson RM, Davenport-Sis NJ, DeRungs LM, Sager MA, Johnson SC, Bendlin BB. Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOEɛ4 Carriers. J Alzheimers Dis. 2015;46(2):525-33. doi: 10.3233/JAD-150072.

Gallagher CL, Bell B, Palotti M, Oh J, Christian BT, Okonkwo O, Sojkova J, Buyan-Dent L, Nickles RJ, Harding SJ, Stone CK, Johnson SC, Holden JE. Anterior cingulate dopamine turnover and behavior change in Parkinson’s disease. Brain Imaging Behav. 2015 Dec;9(4):821-7. doi: 10.1007/s11682-014-9338-4.

Ithapul VK, Singh V, Okonkwo O, Johnson SC. Randomized denoising autoencoders for smaller and efficient imaging based AD clinical trials. Med Image Comput Comput Assist Interv. 2014;17(Pt 2):470-8. doi: 10.1007/978-3-319-10470-6_59.

Schultz SA, Larson J, Oh J, Koscik R, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, Asthana S, Hermann BP, Johnson SC, Sager M, LaRue A, Okonkwo OC. Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer’s disease. Brain Imaging Behav. 2015 Dec;9(4):729-36. doi: 10.1007/s11682-014-9329-5.

Nicholas CR, Okonkwo OC, Bendlin BB, Oh JM, Asthana S, Rowley HA, Hermann B, Sager MA, Johnson SC. Posteromedial hyperactivation during episodic recognition among people with memory decline: findings from the WRAP study. Brain Imaging Behav. 2015 Dec;9(4):690-702. doi: 10.1007/s11682-014-9322-z.

Boots EA, Schultz SA, Oh JM, Larson J, Edwards D, Cook D, Koscik RL, Dowling MN, Gallagher CL, Carlsson CM, Rowley HA, Bendlin BB, LaRue A, Asthana S, Hermann BP, Sager MA, Johnson SC, Okonkwo OC. Cardiorespiratory fitness is associated with brain structure, cognition, and mood in a middle-aged cohort at risk for Alzheimer’s disease. Brain Imaging Behav. 2015 Sep;9(3):639-49. doi: 10.1007/s11682-014-9325-9.

Nowrangi MA, Okonkwo O, Lyketsos C, Oishi K, Mori S, Albert M, Mielke MM. Atlas-based diffusion tensor imaging correlates of executive function. J Alzheimers Dis. 2015;44(2):585-98. doi: 10.3233/JAD-141937.

Okonkwo OC, Schultz SA, Oh JM, Larson J, Edwards D, Cook D, Koscik R, Gallagher CL, Dowling NM, Carlsson CM, Bendlin BB, LaRue A, Rowley HA, Christian BT, Asthana S, Hermann BP, Johnson SC, Sager MA. Physical activity attenuates age-related biomarker alterations in preclinical AD. Neurology. 2014 Nov 4;83(19):1753-60. doi: 10.1212/WNL.0000000000000964.

Okonkwo OC. At the crossroads of preclinical AD and normal brain ageing. Lancet Neurol. 2014 Oct;13(10):965-6. doi: 10.1016/S1474-4422(14)70207-8.

Adluru N, Destiche DJ, Lu SY, Doran ST, Birdsill AC, Melah KE, Okonkwo OC, Alexander AL, Dowling NM, Johnson SC, Sager MA, Bendlin BB. White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer’s disease. Neuroimage Clin. 2014 Apr 21;4:730-42. doi: 10.1016/j.nicl.2014.04.008.

Racine AM, Adluru N, Alexander AL, Christian BT, Okonkwo OC, Oh J, Cleary CA, Birdsill A, Hillmer AT, Murali D, Barnhart TE, Gallagher CL, Carlsson CM, Rowley HA, Dowling NM, Asthana S, Sager MA, Bendlin BB, Johnson SC. Associations between white matter microstructure and amyloid burden in preclinical Alzheimer’s disease: A multimodal imaging investigation. Neuroimage Clin. 2014 Feb 19;4:604-14. doi: 10.1016/j.nicl.2014.02.001.

Li CT, Palotti M, Holden JE, Oh J, Okonkwo O, Christian BT, Bendlin BB, Buyan-Dent L, Harding SJ, Stone CK, DeJesus OT, Nickles RJ, Gallagher CL. A dual-tracer study of extrastriatal 6-[18F]fluoro-m-tyrosine and 6-[18F]-fluoro-L-dopa uptake in Parkinson’s disease. Synapse. 2014 Aug;68(8):325-31. doi: 10.1002/syn.21745.

Okonkwo OC, Oh JM, Koscik R, Jonaitis E, Cleary CA, Dowling NM, Bendlin BB, Larue A, Hermann BP, Barnhart TE, Murali D, Rowley HA, Carlsson CM, Gallagher CL, Asthana S, Sager MA, Christian BT, Johnson SC. Amyloid burden, neuronal function, and cognitive decline in middle-aged adults at risk for Alzheimer’s disease. J Int Neuropsychol Soc. 2014 Apr;20(4):422-33. doi: 10.1017/S1355617714000113.

Kim WH, Singh V, Chung MK, Hinrichs C, Pachauri D, Okonkwo OC, Johnson SC; Alzheimer’s Disease Neuroimaging Initiative. Multi-resolutional shape features via non-Euclidean wavelets: applications to statistical analysis of cortical thickness. Neuroimage. 2014 Jun;93 Pt 1(0 1):107-23. doi: 10.1016/j.neuroimage.2014.02.028.

Koscik RL, La Rue A, Jonaitis EM, Okonkwo OC, Johnson SC, Bendlin BB, Hermann BP, Sager MA. Emergence of mild cognitive impairment in late middle-aged adults in the wisconsin registry for Alzheimer’s prevention. Dement Geriatr Cogn Disord. 2014;38(1-2):16-30. doi: 10.1159/000355682.

Li S, Okonkwo O, Albert M, Wang MC. Variation in Variables that Predict Progression from MCI to AD Dementia over Duration of Follow-up. Am J Alzheimers Dis (Columbia). 2013;2(1):12-28. doi: 10.7726/ajad.2013.1002.

Sacktor N, Nakasujja N, Redd AD, Manucci J, Laeyendecker O, Wendel SK, Porcella SF, Martens C, Bruno D, Skolasky RL, Okonkwo OC, Robertson K, Musisi S, Katabira E, Quinn TC. HIV subtype is not associated with dementia among individuals with moderate and advanced immunosuppression in Kampala, Uganda. Metab Brain Dis. 2014 Jun;29(2):261-8. doi: 10.1007/s11011-014-9498-3.

Johnson SC, Christian BT, Okonkwo OC, Oh JM, Harding S, Xu G, Hillmer AT, Wooten DW, Murali D, Barnhart TE, Hall LT, Racine AM, Klunk WE, Mathis CA, Bendlin BB, Gallagher CL, Carlsson CM, Rowley HA, Hermann BP, Dowling NM, Asthana S, Sager MA. Amyloid burden and neural function in people at risk for Alzheimer’s Disease. Neurobiol Aging. 2014 Mar;35(3):576-84. doi: 10.1016/j.neurobiolaging.2013.09.028.

Griffith HR, Okonkwo OC, Stewart CC, Stoeckel LE, Hollander JA, Elgin JM, Harrell LE, Brockington JC, Clark DG, Ball KK, Owsley C, Marson DC, Wadley VG. Lower hippocampal volume predicts decrements in lane control among drivers with amnestic mild cognitive impairment. J Geriatr Psychiatry Neurol. 2013 Dec;26(4):259-66. doi: 10.1177/0891988713509138.

Birdsill AC, Koscik RL, Jonaitis EM, Johnson SC, Okonkwo OC, Hermann BP, Larue A, Sager MA, Bendlin BB. Regional white matter hyperintensities: aging, Alzheimer’s disease risk, and cognitive function. Neurobiol Aging. 2014 Apr;35(4):769-76. doi: 10.1016/j.neurobiolaging.2013.10.072.

Birdsill AC, Carlsson CM, Willette AA, Okonkwo OC, Johnson SC, Xu G, Oh JM, Gallagher CL, Koscik RL, Jonaitis EM, Hermann BP, LaRue A, Rowley HA, Asthana S, Sager MA, Bendlin BB. Low cerebral blood flow is associated with lower memory function in metabolic syndrome. Obesity (Silver Spring). 2013 Jul;21(7):1313-20. doi: 10.1002/oby.20170.

Engelman CD, Koscik RL, Jonaitis EM, Okonkwo OC, Hermann BP, La Rue A, Sager MA. Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer’s Prevention. J Alzheimers Dis. 2013;36(4):749-57. doi: 10.3233/JAD-130482.

Stoeckel LE, Stewart CC, Griffith HR, Triebel K, Okonkwo OC, den Hollander JA, Martin RC, Belue K, Copeland JN, Harrell LE, Brockington JC, Clark DG, Marson DC. MRI volume of the medial frontal cortex predicts financial capacity in patients with mild Alzheimer’s disease. Brain Imaging Behav. 2013 Sep;7(3):282-92. doi: 10.1007/s11682-013-9226-3.

Gallagher C, Bell B, Bendlin B, Palotti M, Okonkwo O, Sodhi A, Wong R, Buyan-Dent L, Johnson S, Willette A, Harding S, Ninman N, Kastman E, Alexander A. White matter microstructural integrity and executive function in Parkinson’s disease. J Int Neuropsychol Soc. 2013 Mar;19(3):349-54. doi: 10.1017/S1355617712001373. Epub 2013 Jan 15. Erratum in: J Int Neuropsychol Soc. 2013 Apr;19(4):492. Wilette, Auriel [corrected to Willette, Auriel].

Sacktor N, Nakasujja N, Okonkwo O, Skolasky RL, Robertson K, Musisi S, Katabira E. Longitudinal neuropsychological test performance among HIV seropositive individuals in Uganda. J Neurovirol. 2013 Feb;19(1):48-56. doi: 10.1007/s13365-012-0139-5.

Okonkwo OC, Xu G, Oh JM, Dowling NM, Carlsson CM, Gallagher CL, Birdsill AC, Palotti M, Wharton W, Hermann BP, LaRue A, Bendlin BB, Rowley HA, Asthana S, Sager MA, Johnson SC. Cerebral blood flow is diminished in asymptomatic middle-aged adults with maternal history of Alzheimer’s disease. Cereb Cortex. 2014 Apr;24(4):978-88. doi: 10.1093/cercor/bhs381.

Bendlin BB, Carlsson CM, Johnson SC, Zetterberg H, Blennow K, Willette AA, Okonkwo OC, Sodhi A, Ries ML, Birdsill AC, Alexander AL, Rowley HA, Puglielli L, Asthana S, Sager MA. CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer’s disease. PLoS One. 2012;7(6):e37720. doi: 10.1371/journal.pone.0037720.

Okonkwo OC, Xu G, Dowling NM, Bendlin BB, Larue A, Hermann BP, Koscik R, Jonaitis E, Rowley HA, Carlsson CM, Asthana S, Sager MA, Johnson SC. Family history of Alzheimer disease predicts hippocampal atrophy in healthy middle-aged adults. Neurology. 2012 May 29;78(22):1769-76. doi: 10.1212/WNL.0b013e3182583047.

Okonkwo OC, Beech TJ, Jindal M. Re: The importance of an extended preoperative trial of BAHA in unilateral sensorineural hearing loss: a prospective cohort. Clin Otolaryngol. 2012 Feb;37(1):78-9; author reply 79-80. doi: 10.1111/j.1749-4486.2012.02432.x.

Mielke MM, Okonkwo OC, Oishi K, Mori S, Tighe S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG. Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer’s disease. Alzheimers Dement. 2012;8(2):105-13. doi: 10.1016/j.jalz.2011.05.2416.

Okonkwo OC, Cohen RA, Gunstad J, Poppas A. Cardiac output, blood pressure variability, and cognitive decline in geriatric cardiac patients. J Cardiopulm Rehabil Prev. 2011 Sep-Oct;31(5):290-7. doi: 10.1097/HCR.0b013e318220a817.

Bonner-Jackson A, Okonkwo O, Tremont G; Alzheimerʼs Disease Neuroimaging Initiative. Apolipoprotein E ε2 and functional decline in amnestic mild cognitive impairment and Alzheimer disease. Am J Geriatr Psychiatry. 2012 Jul;20(7):584-93. doi: 10.1097/JGP.0b013e3182203c32.

Okonkwo OC, Mielke MM, Griffith HR, Moghekar AR, O’Brien RJ, Shaw LM, Trojanowski JQ, Albert MS; Alzheimer’s Disease Neuroimaging Initiative. Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment. Arch Neurol. 2011 Jan;68(1):113-9. doi: 10.1001/archneurol.2010.334.

Aretouli E, Okonkwo OC, Samek J, Brandt J. The fate of the 0.5s: predictors of 2-year outcome in mild cognitive impairment. J Int Neuropsychol Soc. 2011 Mar;17(2):277-88. doi: 10.1017/S1355617710001621.

Okonkwo OC, Alosco ML, Jerskey BA, Sweet LH, Ott BR, Tremont G; Alzheimer’s Disease Neuroimaging Initiative. Cerebral atrophy, apolipoprotein E varepsilon4, and rate of decline in everyday function among patients with amnestic mild cognitive impairment. Alzheimers Dement. 2010 Sep;6(5):404-11. doi: 10.1016/j.jalz.2010.02.003.

Okonkwo OC, Cohen RA, Gunstad J, Tremont G, Alosco ML, Poppas A. Longitudinal trajectories of cognitive decline among older adults with cardiovascular disease. Cerebrovasc Dis. 2010;30(4):362-73. doi: 10.1159/000319564.

Okonkwo OC, Spitznagel MB, Alosco ML, Tremont G. Associations among measures of awareness of cognitive deficits in dementia. Alzheimers Dement. 2010 Jul;6(4):312-8. doi: 10.1016/j.jalz.2009.06.005.

Triebel KL, Okonkwo OC, Martin R, Griffith HR, Crowther M, Marson DC. Financial capacity of older African Americans with amnestic mild cognitive impairment. Alzheimer Dis Assoc Disord. 2010 Oct-Dec;24(4):365-71. doi: 10.1097/WAD.0b013e3181e7cb05.

Okonkwo OC, Roth DL, Pulley L, Howard G. Confirmatory factor analysis of the validity of the SF-12 for persons with and without a history of stroke. Qual Life Res. 2010 Nov;19(9):1323-31. doi: 10.1007/s11136-010-9691-8.

Okonkwo OC, Alosco ML, Griffith HR, Mielke MM, Shaw LM, Trojanowski JQ, Tremont G; Alzheimer’s Disease Neuroimaging Initiative. Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease. Arch Neurol. 2010 Jun;67(6):688-96. doi: 10.1001/archneurol.2010.118.

Griffith HR, Stewart CC, Stoeckel LE, Okonkwo OC, den Hollander JA, Martin RC, Belue K, Copeland JN, Harrell LE, Brockington JC, Clark DG, Marson DC. Magnetic resonance imaging volume of the angular gyri predicts financial skill deficits in people with amnestic mild cognitive impairment. J Am Geriatr Soc. 2010 Feb;58(2):265-74. doi: 10.1111/j.1532-5415.2009.02679.x.

Griffith HR, Okonkwo OC, den Hollander JA, Belue K, Copeland J, Harrell LE, Brockington JC, Clark DG, Marson DC. Brain metabolic correlates of decision making in amnestic mild cognitive impairment. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2010;17(4):492-504. doi: 10.1080/13825581003646135.

Ott BR, Cohen RA, Gongvatana A, Okonkwo OC, Johanson CE, Stopa EG, Donahue JE, Silverberg GD; Alzheimer’s Disease Neuroimaging Initiative. Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer’s disease. J Alzheimers Dis. 2010;20(2):647-57. doi: 10.3233/JAD-2010-1406.

Triebel KL, Martin R, Griffith HR, Marceaux J, Okonkwo OC, Harrell L, Clark D, Brockington J, Bartolucci A, Marson DC. Declining financial capacity in mild cognitive impairment: A 1-year longitudinal study. Neurology. 2009 Sep 22;73(12):928-34. doi: 10.1212/WNL.0b013e3181b87971..

Okonkwo OC, Griffith HR, Vance DE, Marson DC, Ball KK, Wadley VG. Awareness of functional difficulties in mild cognitive impairment: a multidomain assessment approach. J Am Geriatr Soc. 2009 Jun;57(6):978-84. doi: 10.1111/j.1532-5415.2009.02261.x.

Clay OJ, Edwards JD, Ross LA, Okonkwo O, Wadley VG, Roth DL, Ball KK. Visual function and cognitive speed of processing mediate age-related decline in memory span and fluid intelligence. J Aging Health. 2009 Jun;21(4):547-66. doi: 10.1177/0898264309333326.

Wadley VG, Okonkwo O, Crowe M, Vance DE, Elgin JM, Ball KK, Owsley C. Mild cognitive impairment and everyday function: an investigation of driving performance. J Geriatr Psychiatry Neurol. 2009 Jun;22(2):87-94. doi: 10.1177/0891988708328215.

Crowe M, Andel R, Wadley VG, Okonkwo OC, Sawyer P, Allman RM. Life-space and cognitive decline in a community-based sample of African American and Caucasian older adults. J Gerontol A Biol Sci Med Sci. 2008 Nov;63(11):1241-5. doi: 10.1093/gerona/63.11.1241.

Griffith HR, den Hollander JA, Okonkwo OC, O’Brien T, Watts RL, Marson DC. Brain metabolism differs in Alzheimer’s disease and Parkinson’s disease dementia. Alzheimers Dement. 2008 Nov;4(6):421-7. doi: 10.1016/j.jalz.2008.04.008.

Okonkwo OC, Griffith HR, Copeland JN, Belue K, Lanza S, Zamrini EY, Harrell LE, Brockington JC, Clark D, Raman R, Marson DC. Medical decision-making capacity in mild cognitive impairment: a 3-year longitudinal study. Neurology. 2008 Nov 4;71(19):1474-80. doi: 10.1212/01.wnl.0000334301.32358.48.

Roth DL, Ackerman ML, Okonkwo OC, Burgio LD. The four-factor model of depressive symptoms in dementia caregivers: a structural equation model of ethnic differences. Psychol Aging. 2008 Sep;23(3):567-576. doi: 10.1037/a0013287.

Martin RC, Okonkwo OC, Hill J, Griffith HR, Triebel K, Bartolucci A, Nicholas AP, Watts RL, Stover N, Harrell LE, Clark D, Marson DC. Medical decision-making capacity in cognitively impaired Parkinson’s disease patients without dementia. Mov Disord. 2008 Oct 15;23(13):1867-74. doi: 10.1002/mds.22170.

Okonkwo OC, Wadley VG, Griffith HR, Belue K, Lanza S, Zamrini EY, Harrell LE, Brockington JC, Clark D, Raman R, Marson DC. Awareness of deficits in financial abilities in patients with mild cognitive impairment: going beyond self-informant discrepancy. Am J Geriatr Psychiatry. 2008 Aug;16(8):650-9. doi: 10.1097/JGP.0b013e31817e8a9d.

Stewart CC, Griffith HR, Okonkwo OC, Martin RC, Knowlton RK, Richardson EJ, Hermann BP, Seidenberg M. Contributions of volumetrics of the hippocampus and thalamus to verbal memory in temporal lobe epilepsy patients. Brain Cogn. 2009 Feb;69(1):65-72. doi: 10.1016/j.bandc.2008.05.005.

Okonkwo OC, Wadley VG, Ball K, Vance DE, Crowe M. Dissociations in visual attention deficits among persons with mild cognitive impairment. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2008 Jul;15(4):492-505. doi: 10.1080/13825580701844414.

Wadley VG, Okonkwo O, Crowe M, Ross-Meadows LA. Mild cognitive impairment and everyday function: evidence of reduced speed in performing instrumental activities of daily living. Am J Geriatr Psychiatry. 2008 May;16(5):416-24. doi: 10.1097/JGP.0b013e31816b7303.

Griffith HR, den Hollander JA, Okonkwo OC, O’Brien T, Watts RL, Marson DC. Brain N-acetylaspartate is reduced in Parkinson disease with dementia. Alzheimer Dis Assoc Disord. 2008 Jan-Mar;22(1):54-60. doi: 10.1097/WAD.0b013e3181611011.

Okonkwo OC, Griffith HR, Belue K, Lanza S, Zamrini EY, Harrell LE, Brockington JC, Clark D, Raman R, Marson DC. Cognitive models of medical decision-making capacity in patients with mild cognitive impairment. J Int Neuropsychol Soc. 2008 Mar;14(2):297-308. doi: 10.1017/S1355617708080338.

Okonkwo OC, Sui X, Ahmed A. Disease-specific depression and outcomes in chronic heart failure: a propensity score analysis. Compr Ther. 2007 Summer;33(2):65-70. doi: 10.1007/s12019-007-8001-z.

Griffith HR, Okonkwo OC, O’Brien T, Hollander JA. Reduced brain glutamate in patients with Parkinson’s disease. NMR Biomed. 2008 May;21(4):381-7. doi: 10.1002/nbm.1203.

Okonkwo OC, Crowe M, Wadley VG, Ball K. Visual attention and self-regulation of driving among older adults. Int Psychogeriatr. 2008 Feb;20(1):162-73. doi: 10.1017/S104161020700539X.

Griffith HR, Hollander JA, Okonkwo O, Evanochko WT, Harrell LE, Zamrini EY, Brockington JC, Marson DC. Executive function is associated with brain proton magnetic resonance spectroscopy in amnestic mild cognitive impairment. J Clin Exp Neuropsychol. 2007 Aug;29(6):599-609. doi: 10.1080/13803390600826595.

Hochhalter AK, Stevens AB, Okonkwo O. Structured practice: a memory intervention for persons with dementia. Am J Alzheimers Dis Other Demen. 2006 Dec-2007 Jan;21(6):424-30. doi: 10.1177/1533317506292328.

Okonkwo OC, Wadley VG, Griffith HR, Ball K, Marson DC. Cognitive correlates of financial abilities in mild cognitive impairment. J Am Geriatr Soc. 2006 Nov;54(11):1745-50. doi: 10.1111/j.1532-5415.2006.00916.x.