Researching Modifiable and Non-Modifiable Risk Factors Linked to Cognitive Resilience in Alzheimer’s Disease
What do we do?
Our lab focuses on clarifying how alterations in the brain and other biomolecules (such as cerebrospinal fluid β-amyloid) place some cognitively-normal individuals on a pernicious trajectory that culminates in Alzheimer’s dementia. In this context, we are also interested in discovering new knowledge concerning the modulation of the link between brain changes and cognitive decline by both modifiable (e.g., cognitively-stimulating activities, physical exercise) and non-modifiable (e.g., genetic vulnerability) factors.
We use many techniques in our research, including but not limited to:
This is an accordion element with a series of buttons that open and close related content panels.
MRI and PET Imaging
Cerebrospinal Fluid Collection
Maximal Exercise Testing
Blood-based Protein Analysis (eg klotho, BDNF, etc.)
Physical Activity Monitoring
We are a part of the larger Wisconsin Alzheimer’s Disease Research Program, which includes both the Wisconsin Alzheimer’s Disease Research Center and the Wisconsin Alzheimer’s Institute.
Our offices are located on UW Madison’s campus within the UW Hospital. The majority of our research is conducted within the UW Hospital, the Waisman Center, the Wisconsin Institute for Medical Research, and the YMCA.
Ozioma Okonkwo has been appointed to serve on several committees over the last few months: The NIH-NINDS Multiple Etiology Dementias (MED) committee for the 2022 NIH Alzheimer’s Disease-Related Dementias (ADRD) Summit. When approved by the …October 12, 2021
Four members of the Okonkwo Lab had their abstracts accepted for oral or poster presentation at the Alzheimer’s Association International Conference (AAIC) Neuroscience Next 2021! Max Gaitán: Circulating klotho is elevated in cerebrospinal fluid, but …October 12, 2021
Two manuscripts were accepted for publication this summer: Max Gaitán’s manuscript was published in Frontiers in Endocrinology: Effects of Aerobic Exercise Training on Systematic biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer’s Disease …October 12, 2021
Natascha Merten, PhD joined the Okonkwo Lab on September 1st as an Assistant Scientist. We are thrilled to have her join us!October 12, 2021
- More News