This study was concluded in 2019, thank you to everyone who dedicated themselves to it and made it a great success!

The Overall Aim

Rigorously characterize the relationship between cardiorespiratory fitness—an indicator for habitual physical activity—and AD biomarkers and cognition in 200 at-risk, middle-aged adults enrolled in the Wisconsin Registry for Alzheimer’s Prevention (WRAP) and the Wisconsin Alzheimer’s Disease Research Center (WADRC); and preliminarily assess the biological mechanisms by which CRF affects AD biomarkers and cognition.

Study Procedures

  • Consent
  • fasting from food and medications
  • Vitals
  • Blood draw (two, one before and and one after the exercise test)
  • MRI, brain scans
  • Maximal effort exercise test walking on an inclined treadmill
  • Lumbar Puncture
  • Actigraph at home for 7 days following the visit date